The situation changed for Michael and for millions of other schizophrenics, for better and worse, around 1953, when the first tranquilizer-a drug called Largactil in England, Thorazine in the United States-became available. The tranquilizers could damp down and perhaps prevent the hallucinations and delusions, the "positive symptoms" of schizophrenia, but this could come at great cost to the individual.
( Oliver Sacks )
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