The quote "A bus cuts the world in half" from Jodi Picoult's novel "My Sister's Keeper" metaphorically illustrates a significant moment of separation or transformation in life. It represents how an event or decision can drastically change the course of one's life, splitting it into before and after. This notion resonates throughout the narrative, as the characters grapple with profound choices that affect their relationships and identities.

In "My Sister's Keeper," the story delves into complex family dynamics and ethical dilemmas surrounding medical choices. The symbolism of the bus highlights the pivotal moments that define the characters' paths and the emotional journeys they undertake. As the characters navigate their intertwined lives, the quote emphasizes the fragility of their connections and the impact of unforeseen events on their futures.