The quote "A saguaro can fall for a snowman but where would they set up house?" from Jodi Picoult's "Plain Truth" reflects the idea of unlikely relationships and the challenges they face. The saguaro cactus, native to the desert, represents a tough, resilient character, while the snowman symbolizes a temporary, fleeting existence. This juxtaposition highlights the contrasts in their environments and lifestyles, suggesting that even feelings of attraction can be complicated by fundamental differences.

In this context, the question of where they would "set up house" emphasizes the practical challenges of bridging two vastly different worlds. It suggests that while love may transcend boundaries, the realities of life and location can pose significant obstacles. The imagery evokes a sense of longing and the exploration of how two distinct entities can navigate their feelings in a world that may not be conducive to their union.