In her novel "Blonde," Joyce Carol Oates explores the complex and often isolating nature of acting. The profession is portrayed as one that, despite its outward glamour, can leave individuals feeling profoundly alone. The demands of embodying different characters and the public scrutiny faced by actors contribute to a deep sense of solitude.

This sentiment is encapsulated in the quote, "Acting is the loneliest profession I know." Oates brings to light the emotional toll that this profession can take, illustrating how success and fame do not necessarily equate to personal fulfillment or connection with others.