The quote reflects on the common human experience of making commitments and failing to follow through. The speaker has observed people repeatedly missing appointments, each offering an explanation for their absence. This suggests that while there may be numerous excuses, they all stem from a singular underlying reason that transcends individual circumstances.

The essence of this reflection points to a deeper truth about human behavior and accountability. Despite the variety of situations people encounter, the speaker implies that there is a universal cause for their failure to meet obligations, encouraging a consideration of what truly drives our actions and decisions.