The quote from "Lonesome Dove" by Larry McMurtry reflects a profound insight into human emotion and experience. It suggests that sometimes the enjoyment of pleasure can lead to a deeper suffering when it is lost or unattainable. This perspective implies that ignorance of joy can be less painful than the distress that follows experiencing it.

This sentiment resonates with many aspects of life, indicating that the highs of pleasure can often be accompanied by the lows of disappointment. It promotes a contemplation of the costs of emotional experiences, encouraging readers to consider whether the joy of certain pleasures is worth the potential heartache that may follow.