In Ken Kesey's novel "Sometimes a Great Notion," the theme of seeking meaning and connection in relationships is central to the characters’ experiences. The desire to be significant to someone else drives their actions and decisions throughout the narrative. This longing reflects a universal human need for belonging and recognition within a community.

The quote "but mostly, I guess, I want to really mean something to somebody" encapsulates this sentiment. It speaks to the core of human emotions, emphasizing the importance of making an impact in the lives of others. Through various struggles and interactions, the characters illustrate how their lives are intertwined and how personal fulfillment often hinges on these connections.