In "Ulysses," James Joyce explores the concept that drug use accelerates the aging process, particularly after experiencing heightened mental stimulation. The intense reactions that come from this period of excitement lead to a state of lethargy, suggesting that the body and mind require recovery from such extremes.

The phrase implies a profound transformation occurs over time due to drug use, suggesting that a lifetime of experiences and changes can take place within a single night. This gradual shift in one's character points to the deeper consequences of substance use, reflecting on how it alters individuals fundamentally.