This quote touches on the profound idea of divine omniscience, emphasizing that ultimate understanding and knowledge rest with a divine entity rather than humans. It invites reflection on the limits of human comprehension and the humility required to accept that some matters are beyond our grasp. In many philosophical and spiritual traditions, the notion that only a higher power possesses full knowledge encourages humility, trust, and surrender to that which we cannot control or fully understand.

From a human perspective, this quote might serve as a reminder of the uncertainties and mysteries inherent in life. No matter how much we learn or how progress in science or philosophy, there remains a realm of unknowns where divine insight is said to reside. Recognizing that "God only knows the issue" can provide comfort in times of crisis or confusion, suggesting that while we may struggle with questions, struggles, and plans, ultimate answers are known only to a higher power.

This acknowledgment can also foster empathy and patience, both with oneself and others. It implies that sometimes, it's okay not to have all the answers, and that acceptance of this fact allows us to focus on our immediate responses rather than obsessing over solutions beyond our reach. In a broader sense, it encourages a sense of trust—trust in the divine wisdom and timing, even when current circumstances seem uncertain or troubling.

Thus, the quote encapsulates a humble acknowledgment of human limitations and an appeal to divine omniscience as the ultimate arbiter of understanding. It celebrates the mystery of life and encourages humility in the face of the unknown, ultimately fostering a sense of peace amidst life's inevitable uncertainties.