In "Second Glance," Jodi Picoult explores the theme of confronting the unseen challenges and antagonists in life. The quote, "How could you beat an enemy you couldn't see?" encapsulates the struggle of dealing with vague fears and invisible threats, suggesting that true battles often lie within ourselves or in the mysteries of life we don't fully understand.

This idea resonates with the human experience, highlighting the mental and emotional battles we face. It prompts readers to consider how to navigate difficulties that can’t be logically identified, thereby encouraging self-reflection and resilience in the face of uncertainty.