The quote reflects the speaker's frustration and despair regarding communication with a family member, specifically her sister. The suggestion that the phone number 401-GO2-HELL is out of service implies a deep rift or conflict within the family, highlighting the emotional distance between them.
This sentiment points to the themes of estrangement and longing for connection that are prevalent in Jodi Picoult's "My Sister's Keeper." The choice of a mock phone number suggests a blend of sarcasm and hurt, encapsulating the struggle for understanding and reconciliation in difficult family dynamics.