In the quote, there is a humorous emphasis on the severity of the grandmother's Alzheimer's disease, referring to it as "Irish Alzheimer's" to suggest a cultural or comedic angle. The phrase indicates that her memory loss is extensive, yet she still retains her strong feelings and grudges, highlighting how emotions and memories linked to resentment can persist even as other memories fade.

This depiction serves as a lighthearted commentary on how certain traits or memories may remain intact despite cognitive decline. It also touches on the humorous yet poignant reality of aging and disease, where old grievances may linger longer than more recent memories, offering a glimpse into the complexities of memory and personality in Alzheimer's patients.