The quote expresses a common belief that misfortune or adverse circumstances typically don't recur in the same situation. However, it challenges this notion by stating that it can indeed happen, especially if one fails to learn from past experiences and remains in the same place. The idea implies a sense of responsibility for one's choices and actions, suggesting that recognizing patterns and making changes is crucial to avoiding repeated mistakes.

In the context of Jodi Picoult's "My Sister's Keeper," this sentiment reflects the themes of personal growth, resilience, and the importance of adapting to life's challenges. It emphasizes that individuals must be proactive in seeking change to prevent facing similar trials again, reminding readers to heed lessons from the past to avoid future struggles.