In "Lonesome Dove," Larry McMurtry explores the tenacity of human desires through a character's perspective on renting pigs. The quote highlights how strong motivation can drive a person towards their goals, regardless of obstacles. This reflects a broader theme of determination, showcasing how passion can influence one's choices and actions. A person willing to pursue an unusual idea, like renting pigs, exemplifies the lengths individuals will go to fulfill their ambitions.

The statement also emphasizes a sense of frustration when faced with limitations. The phrase "mighty upset" suggests that those who have a clear vision or desire will seek ways to achieve it, even if the journey is complicated. This notion resonates throughout "Lonesome Dove," illustrating the struggles and conflicts faced by characters as they chase their dreams amidst the challenges of life. McMurtry captures the essence of human resolve in the pursuit of personal aspirations.