The quote "If you don't know there's an alternative, you can't miss it" from Jodi Picoult's book "Handle with Care" highlights the idea that without awareness of different options or perspectives, one is unable to feel the impact of missing out on those choices. This suggests that knowledge and awareness play a crucial role in our decision-making and fulfillment in life. When faced with a situation, realizing there could be different pathways can influence how we perceive our circumstances.

In the context of Picoult's work, which often explores complex moral dilemmas, the quote may imply that understanding various alternatives is essential for personal growth. It emphasizes that discovery and exploration can open up opportunities that might lead to a richer, more satisfying life. By being conscious of the possibilities around us, we allow ourselves to weigh our decisions more effectively and consider what truly aligns with our values and desires.