The quote emphasizes the idea that life is unpredictable and fraught with dangers that cannot be completely prepared for, regardless of how rigorous one's training may be. It suggests that experience and real-world challenges often reveal unforeseen risks that a person may not have anticipated, highlighting the limitations of preparation in the face of life's complexities.

In the context of "Lonesome Dove," this perspective resonates with the characters' journeys and the various trials they face. It underscores the theme that despite their skills and knowledge, the unpredictability of life ultimately presents challenges that require adaptation and resilience beyond what training can provide.