In Barbara Kingsolver's novel "The Poisonwood Bible," the characters experience profound transformations that reflect the unsettling nature of change. The quote highlights the fear and discomfort that arise when familiar aspects of life become unrecognizable. This sentiment is particularly relevant as it addresses the emotional turmoil that comes with unexpected changes, especially regarding things and people we hold dear.

The journey of the characters throughout the story emphasizes the impact of cultural upheaval and personal growth. As they navigate a new environment, the changes they encounter challenge their perceptions and beliefs. This theme resonates with the reader, illustrating how deeply rooted attachments can be shaken, evoking a sense of vulnerability in the face of life’s unpredictability.