The quote "Life makes everybody strange, if you keep living long enough" from Larry McMurtry's book "Lonesome Dove" encapsulates the essence of human experience and the inevitability of change over time. It suggests that as people navigate through life's challenges and adventures, they often end up transformed, sometimes in unexpected ways. This transformation can be both profound and subtle, revealing hidden layers of personality and experience.

In "Lonesome Dove," this idea resonates deeply as characters face the trials of their journey. The impact of time, adversity, and relationships shapes them uniquely. The novel illustrates how life’s circumstances can lead to peculiar behaviors and perspectives, ultimately highlighting the shared journey of humanity in confronting life's strangeness. The narrative reflects that embracing these changes is part of what makes life rich and complicated.