In "The Devil in the White City," Erik Larson intertwines the stories of the 1893 Chicago World's Fair and the serial killer H.H. Holmes. The narrative explores the architectural marvels of the fair alongside the dark deeds of Holmes, capturing the spirit of ambition and the underlying menace of human nature. The fair symbolizes innovation and progress, while Holmes epitomizes the lurking dangers that can accompany such greatness.

The quote "Make no little plans; they have no magic to stir men's blood" reflects the book's overarching themes of grand aspirations versus sinister realities. It suggests that true ambition should inspire and evoke strong emotions, a concept vividly illustrated by the fair's grandeur and Holmes' chilling actions. Larson draws a contrast between the dazzling achievements of the fair and the horrors concealed within the city's shadows.