This quote from Mark Helprin's "Winter's Tale" reflects the unpredictability of life and the absence of guarantees regarding our actions and their consequences. It emphasizes that we often cannot foresee the impact of our choices, nor can we expect clear answers or validation like in scientific endeavors. Life's complexities and uncertainties are intrinsic to the human experience.

Moreover, the quote encourages embracing the unknown and the journey through uncertainty. It suggests that worthwhile experiences often come from navigating through challenges without the assurance of clarity or success. In essence, Helprin highlights the beauty of life's ambiguity and the significance of living fully despite the lack of certainty.