Some characters in the world are marked for self-destruction, and no matter how much rational reasoning is offered, it cannot change their destructive path. This suggests a tragic aspect of human nature where certain individuals are inclined toward self-inflicted harm, despite logic or advice from others.
Lawrence Durrell's quote highlights the difficulty in convincing individuals who are on a self-destructive course, emphasizing that internal struggles often resist external persuasion. It reflects on the deeper, sometimes irreversible, choices that some characters or people make in life.