In "Lonesome Dove," the protagonist, July, grapples with a profound sense of uncertainty in his life. His wife’s departure and the absence of his deputy add to his feelings of isolation and confusion. These unexplained absences lead him to ponder the unpredictability of his surroundings and relationships.

The irony of his situation amplifies his internal conflict, as he is tasked with tracking down a man who is also lost to the unknown. This state of affairs signifies a pivotal moment in July's life, leaving him in a realm where familiarity has faded, and he struggles to find clarity in his circumstances.