In Cecelia Ahern's novel "One Hundred Names," the story explores the theme of emotional fulfillment and the innate sense that something vital is absent from one's life. The heart symbolizes a deeper understanding of personal needs, highlighting how it can struggle when there is an absence of connection or purpose.

The quote reflects the internal struggle individuals face when their true desires are unfulfilled. It emphasizes that the heart, as a representation of our feelings and intuitions, works tirelessly to compensate for what is lacking, illustrating the relentless pursuit of happiness and authenticity in life.