The quote "The Wonderlust--probably it's a worse affliction than the Wanderlust" from Sinclair Lewis's novel "Main Street" suggests that the desire for curiosity and exploration of ideas can be more detrimental than the traditional yearning to travel. This "Wonderlust" reflects an insatiable need to seek out intellectual and cultural experiences, which might lead to dissatisfaction or discontent in one's surroundings.

Lewis seems to be highlighting how the pursuit of broader experiences, rooted in curiosity, can create unease when one feels trapped in mundane life. This affliction may drive individuals to constantly seek new stimuli, possibly overshadowing the appreciation of their current environment and relationships.