The quote "There are those who are made different in the womb," from James Lee Burke's book "Wayfaring Stranger," suggests that some individuals are inherently unique from birth. This notion implies that certain traits or destinies are predetermined, influencing how a person interacts with the world and experiences life. The phrase evokes a sense of inevitability regarding one's identity and the paths they may follow, highlighting the complexity of human existence.

In the larger context of the narrative, this theme of predetermined differences might reflect the broader exploration of identity, fate, and individuality. Burke often delves into characters shaped by their circumstances and innate qualities, suggesting a deep connection between one’s origins and their future. The idea prompts readers to consider the impact of their origins on their choices and the lives they lead.