The quote reflects a poignant image of two individuals consuming alcohol, likening it to a remedy for their sorrow. The phrase "red liquor" suggests a rich, possibly strong drink, while "sadness medicine" implies that they are using alcohol to cope with their emotional pain. This portrayal invites readers to consider the deeper implications of using substances as a means to escape reality and deal with personal struggles.

In Thomas Pynchon's "Against the Day," this image resonates with themes of escapism and the human condition. The characters' choice to drink signifies their attempt to confront or dull their unhappiness. Thus, the quote encapsulates a moment of vulnerability and introspection, highlighting how individuals often seek solace in fleeting pleasures to mask their grief.