In the quote, the speaker addresses Chrissy, suggesting that her grandmother's Alzheimer's disease has progressed significantly. The condition, referred to as Irish Alzheimer's, has caused her to lose many memories, but surprisingly, her resentment and grudges remain vivid in her mind.
This humorous yet poignant remark highlights how certain emotional memories, like grudges, can persist even when other mental faculties decline. It reflects the complex nature of memory and how personal history and feelings can endure despite the effects of aging or illness.