The quote "Women readers kept fiction alive—here was another one" reflects the significant role that female readers have played in sustaining and promoting literature throughout history. In John Irving's "Avenue of Mysteries," this acknowledgment showcases the deep connection between women and storytelling, emphasizing how their support has contributed to the evolution of fiction. This highlights not only the importance of readers but also the impact of gender dynamics in the literary world.

Irving's novel illustrates the diverse experiences and perspectives that women bring to literature, which enriches narratives and fosters a deeper understanding of the human experience. By recognizing the contribution of women readers, the author underscores the essential relationship between audiences and writers, suggesting that literature thrives on engagement and a shared love for stories. This mutual influence is celebrated in "Avenue of Mysteries," affirming the pivotal role women have played in keeping literature vibrant and relevant.