In "Lonesome Dove" by Larry McMurtry, the quote reflects the characters' perception of strength and the nature of their troubles. It suggests that they are so accustomed to their own challenges that facing something new would be a refreshing change. The sentiment implies a contrast between internal and external conflicts, emphasizing how the familiar can feel more comfortable, even when it is burdensome.

This perspective reveals the complexity of human experiences and relationships, showcasing how people adapt to their struggles. The dialogue adds depth to the themes of resilience and the monotony of hardship, highlighting a desire for novelty amidst daily struggles. The characters seem to acknowledge that they are self-sufficient in managing their adversities, yet they still yearn for something different to shake up their routine.