You have little to no response to AAV the first time your body sees it. If you used the same vector twice you would want to bump up immunosuppression. I believe there will be many new ways to deliver genes in the future as well.
This quote highlights the challenges and possibilities in gene therapy, particularly related to immune responses to vectors like AAV (Adeno-Associated Virus). It underscores the importance of understanding immune reactions to improve treatment efficacy and the potential for innovation in gene delivery methods. Advances in this field could significantly enhance our ability to treat genetic disorders with fewer side effects. The future of gene therapy looks promising as scientists explore novel delivery techniques that can bypass immune barriers, making treatments more effective and accessible.
