"You only have one chance to make a first impression" emphasizes the importance of how you present yourself initially, as first impressions can significantly influence others' perceptions of you. This idea encourages mindfulness and effort when meeting new people or entering new situations to leave a positive mark.

In Stephanie Perkins' "Lola and the Boy Next Door," this quote underlines the significance of first impressions in personal relationships, highlighting how initial encounters can shape future interactions. Making a good first impression can open doors to new opportunities and meaningful connections.