The quote expresses a deep dissatisfaction with the course of human history and a longing for its complete erasure. The speaker does not wish for a mere end but rather for humanity to vanish entirely, including all memories and legacies. This yearning reflects a profound disillusionment with human achievements and the burdens associated with historical events and figures.

The reference to notable historical figures like Nero, Napoleon, Buddha, and Christ illustrates a critique of how their legacies weigh on humanity. The mention of a "first foolish woman" emphasizes a sense of tragic innocence and the complexities of existence, conveying a desire to escape the pains and mistakes inherent in human life.