In Jodi Picoult's novel "My Sister's Keeper," the complexities of motherhood are explored through the struggles of the characters. The quote highlights the never-ending responsibilities of a mother, suggesting that once a woman takes on this role, it becomes a full-time commitment with no breaks. The narrative delves into the emotional and ethical dilemmas faced by parents, particularly when their children's lives are intertwined in challenging circumstances. The story centers around a family's crisis as they navigate the delicate dynamics of health, love, and moral choices. Each character grapples with their own sacrifices and decisions, shedding light on what it truly means to be a mother. The quote encapsulates the idea that motherhood is a relentless, 24/7 commitment, emphasizing the sacrifices that often go unseen in this profound role.

Once you sign on to be a mother, that's the only shift they offer.

In this context, the quote reflects the perpetual nature of motherhood, underscoring the emotional weight mothers bear and the sacrifices they make for their children.