In "The Year of Lear: Shakespeare in 1606," James Shapiro explores the themes of aging and timelessness in Shakespeare's works. The quote "Age cannot wither her, nor custom stale her infinite variety" reflects the idea that true beauty and complexity remain unaffected by the passage of time. This notion resonates throughout Shakespeare's characters, highlighting their enduring nature and the universal human experiences they represent.

Shapiro's analysis reveals how Shakespeare captures the struggles of his characters against inevitable change, particularly in the context of love, desire, and identity. The quote underscores the tension between the permanence of certain qualities and the impermanence of life, suggesting that while individuals may age, their essence and the impact they have on others can remain vibrant and significant.