The quote reflects the disillusionment with the realities of pursuing a career in poetry, suggesting that many talented poets ultimately find themselves relegated to teaching positions. Nabokov's transition to English literature indicates a shift from creative aspirations to a more conventional profession, perhaps highlighting the struggle and compromise often faced by artists.
By mentioning "pipe-smoking teachers in tweeds," Nabokov paints a vivid image of the stereotype associated with academic life, contrasting the idealized vision of a poet with the mundane existence of educators. This juxtaposition serves as a commentary on the sacrifices and changes one makes in search of stability and practicality in their professional lives.