In Edgar Allan Poe's "The Murders in the Rue Morgue: The Dupin Tales," the quote suggests that even individuals who treat life and death with indifference recognize certain things as deserving of reverence. This notion highlights a universal truth about human experience—regardless of one's perspective on mortality, there are aspects of life that command respect and seriousness.

This statement reflects the complexity of the human condition, where feelings towards existence may fluctuate. Some may view life as a series of jokes, yet in moments of contemplation, they acknowledge the significance of certain values or principles that transcend their jesting. Thus, Poe invites readers to consider what remains sacred amidst humor and triviality.