In John Updike's novel "Rabbit, Run," the protagonist confronts the influence of others on his choices and behavior. The quote "Everybody who tells you how to act has whiskey on their breath" suggests that those who offer advice on how to live often do so from a place of personal flaw or indulgence. This implies a certain hypocrisy in the counsel given by people who may not be leading by the best example. It reflects a skepticism towards the motives and wisdom of others who attempt to guide one's actions.

This sentiment resonates with the theme of personal freedom versus societal expectations in the novel. The character struggles to assert his identity amidst the pressures to conform. By recognizing the flawed nature of those who impose their views, the protagonist seeks to carve out his own path, unencumbered by the expectations of others. This exploration of self-determination and the rejection of external judgment highlights the complexity of navigating personal decisions in a world filled with conflicting advice.