The quote "Everybody who tells you how to act has whisky on their breath" from John Updike's novel "Rabbit, Run" suggests a critique of those who offer advice on morality and behavior. It implies that such advice often comes from individuals who may themselves be flawed or hypocritical, perhaps engaging in their own vices. This sets up a tension between societal expectations and personal authenticity.

This line encapsulates the theme of the book, where the protagonist, Harry "Rabbit" Angstrom, grapples with societal pressures. It highlights the conflict between adhering to external norms and pursuing one's true desires, emphasizing that often, those who judge others may not be in the best position to do so.