In "Redshirts," author John Scalzi addresses the feelings of existential doubt and significance that individuals may grapple with in their lives. He emphasizes that while one might feel small and unimportant within the vastness of the universe, this realization shouldn't paralyze them. Instead, it's essential to recognize one's unique role and contributions, even if they seem minor in the grand scheme of things.

Scalzi encourages readers to embrace their creativity and the joy of storytelling rather than succumbing to existential worries. He highlights the privilege of being able to create narratives and engage in fulfilling work, suggesting that facing life's challenges with a mature perspective is crucial. In essence, he pushes for an acceptance of one's position in the universe, coupled with a proactive approach to personal and professional life.