In "Fear and Loathing in Las Vegas," Hunter S. Thompson conveys the harsh reality of Las Vegas for those who struggle with failure. The quote "For a loser, Vegas is the meanest town on earth" encapsulates the city's unforgiving nature, particularly for individuals who find themselves at a low point in their lives. It reflects the idea that success is often celebrated in the city, while failure is met with disdain and hardship.

Thompson's work paints a vivid picture of the disparity between dreams and reality in Las Vegas. The city, often seen as a place of opportunity and excitement, can be particularly cruel to those who do not fit the mold of success. Through this lens, Thompson critiques the broader American culture that idolizes winning, leaving those perceived as 'losers' to navigate a landscape that feels relentless and punishing.