In George Eliot's "Middlemarch," the quotation highlights the powerful influence external circumstances have on individuals. It suggests that no matter how resilient or strong a person may appear inwardly, their thoughts, actions, and character are significantly shaped by their environment and societal conditions. This perspective emphasizes the interconnectedness of individuals with the world around them, indicating that external factors play a crucial role in personal development.

The idea prompts readers to reflect on how external influences, such as social norms, relationships, and economic conditions, can impact one's inner strength and choices. Eliot's work often examines the struggles of her characters, illustrating that while individuals strive for autonomy, they remain deeply affected by their surroundings, thus portraying the complexity of human experience in navigating personal desire against societal expectations.