In "House Rules" by Jodi Picoult, the narrative centers on the complexities of human behavior and relationships. The protagonist struggles to understand the motivations of those around him, underlining the idea that people often act in ways that are baffling or illogical. This theme resonates throughout the book, as it explores issues of family dynamics, social perceptions, and the challenges that come with differing perspectives.

The quote "Frankly, people don't make sense to me" encapsulates a central premise of the story, shedding light on the protagonist's feelings of alienation and confusion in navigating a world filled with unpredictable interactions. Through this lens, Picoult delves deep into the human psyche, illustrating how personal experiences shape our understanding and reactions to others. Ultimately, it raises questions about empathy and the nature of relationships.