In "House Rules," author Jodi Picoult draws a comparison between cats and individuals with Asperger's, suggesting that both share certain traits. She highlights their intelligence, indicating that both are capable of smart behaviors and independent thinking. This connection suggests an understanding of the unique characteristics of those on the autism spectrum.

Furthermore, Picoult emphasizes the necessity for personal space and solitude for both cats and people with Asperger's. Just as cats may retreat to a quiet spot when they need time alone, individuals with Asperger's also require moments of solitude to recharge and process their thoughts, reinforcing the idea of respecting personal boundaries.