The quote sharply critiques the practical application of realpolitik — a political philosophy centered on pragmatic and strategic rather than ethical considerations. Hitchens points out that instead of establishing lasting governance or stability, realpolitik often exacerbates divisions. The reference to Henry Kissinger's 1972 visit to the Shah of Iran contextualizes this assessment historically: that era marked significant U.S. involvement in Iranian politics, prioritizing strategic alliances over democratic values or popular rule.

This has led to profound consequences, such as political disenfranchisement, social fracture, and eventually tumultuous outcomes like the Iranian Revolution of 1979. The "harvest" metaphor highlights the long-term results of policies that focus on power calculus rather than justice or popular welfare. It prompts reflection on how political strategies rooted purely in power politics risk fostering instability and alienation instead of constructive governance.

In a broader sense, the quote challenges the effectiveness of using cunning and opportunism as substitutes for ethical leadership. It suggests that tyranny or authoritarian control achieved through manipulation may ultimately fracture societies rather than unify them. This resonates today, as many international interventions and political maneuvers can be seen through this lens, raising enduring questions about means and ends in politics.

Ultimately, Hitchens' statement is a call to critically evaluate the implications of realpolitik beyond immediate tactical victories, urging awareness of its divisive long-term consequences on nations and peoples.