The quote reflects on the idea of human inequality and the various sizes people come in, both literally and metaphorically. It suggests that while God created individuals with differing attributes, Colt's invention of the .45 revolver has the capacity to level the playing field in some way, implying a confrontational aspect to humanity's struggles. This can symbolize the conflicts arising from social disparities, as a firearm can empower anyone regardless of their physical stature.

In Don DeLillo's book "Libra," this notion emphasizes the complexity of human relationships and power dynamics. The juxtaposition of divine creation and human innovation suggests that while we might be born into different circumstances, there are tools and means that can alter the balance of power. This raises questions about violence, control, and the lengths to which individuals will go to assert themselves in a world that often feels unfair.