The quote "Good-bye healthy life and hullo rubber knickers and support hose?" reflects a humorous yet relatable sentiment about the changes that come with aging or facing health challenges. The character expresses a sense of loss regarding a vibrant and active lifestyle, contrasting it with the unappealing imagery of necessary but uncomfortable items like rubber undergarments and supportive hosiery that often become associated with aging.

This line encapsulates Agatha Raisin's candid attitude towards life's inconveniences, blending wit and realism. It highlights the absurdity of medical necessities while illustrating how these experiences can alter one's perception of health and vitality. The author, M.C. Beaton, uses this humor to create a connection between Agatha and readers, who may share similar feelings about the passage of time and its impact on daily life.