In "The Ghost Writer," Philip Roth explores the recurring theme of artistic persecution throughout history. Great artists often face hostility and backlash from those who are intimidated by their talent and creativity. This persecution frequently comes from individuals who lack the knowledge or understanding to appreciate the artist's work, leading to an environment where fear reigns over admiration.

Roth emphasizes how this harsh treatment of artists reflects a broader societal tendency to reject what is different or challenging. The book illustrates the struggle between the visionary and the masses, highlighting the challenges that artists encounter as they pursue their craft in a world that may not always recognize their value or contributions.