In this quote from James Patterson's book The Final Warning, the warning suggests that playing poker with someone who can read minds is a risky endeavor. The idea emphasizes that having such an advantage makes the game unfair, as the person with mind-reading abilities can predict moves and strategies, leading to an almost unbeatable position.

It also highlights the importance of knowing your opponents' skills and limitations. The statement serves as a humorous reminder that some advantages, like mind-reading, can significantly alter the outcome of a game, making it wise to avoid engaging in activities where the odds are heavily skewed by extraordinary abilities.