The quote from Jeffrey Eugenides' novel "Middlesex," suggesting that people ceased to be human in 1913, can be interpreted as a commentary on the transformative and often dehumanizing effects of modernity and industrialization. This period marked significant social, political, and technological changes that altered human interactions and experiences profoundly. The narrative may imply a loss of connection to core human values and emotions as societies shifted towards mechanization and urbanization.

In "Middlesex," Eugenides explores themes of identity, culture, and the impact of historical events on individual lives. The mention of 1913 serves as a pivotal point, perhaps reflecting the onset of modern challenges that strip away humanity's essence. It encourages readers to consider the implications of rapid advancement and societal shifts on our intrinsic human nature and relationships, prompting a reflection on what it means to be truly human in the face of relentless change.