In Jeffrey Eugenides' novel "Middlesex," the central theme revolves around the complexities of identity and personal discovery. The story follows the life of Calliope Stephanides, who undergoes a profound transformation, reflecting on the challenges of navigating gender and heritage. The narrative delves into the intricacies of familial relationships and the impact of ancestry on individual identity.

The quote, "The matter with us is you," highlights the pivotal role of personal connections and the influence one individual can have on a broader community. It emphasizes the significance of self-awareness and the understanding that every person’s existence shapes the experiences of others, making the exploration of one's identity not just an individual journey, but a shared one.